Ovarian cancer

Of all gynecologic malignancies, ovarian tail assemblycer continues to concord the highest mortality rate rate and is the most difficult to diagnose. In the United States feminine population, ovarian pubic louse ranks fifth in absolute mortality among cancer related deaths (13,000/yr). In most reported cases, ovarian cancer, when first diagnosed is in stages 3 or IV in about 60 to 70% of patients which further complicates treatment of the illness (Barber, 3). Early detection in ovarian cancer is hampered by the lack of appropriate neoplasm markers and clinically, most patients fail to hold up significant symptoms until they reach advanced stage disease. The characteristics of ovarian cancer have been studied in primary tumors and in realized ovarian tumor cellular telephone lines which provide a reproducible source of tumor material. Among the major clinical problems of ovarian cancer, malignant progression, rapid emergence of drug resistance, and associated cross -resistance remain unresolved. ovarian cancer has a high frequency of metastasis yet chiefly remains situate within the peritoneal cavity. Tumor k like a shotledge has been associated with aberrant, dysfunctional view and/or mutation of various genes. This can include oncogene overexpression, increase or mutation, aberrant tumor suppressor expression or mutation. Also, subversion of forces antitumor tolerant responses may play a contribution in the pathogenesis of cancer (Sharp, 77).

Ovarian clear cell glandular carcinoma was first rear forth by Peham in 1899 as hypernephroma of the ovary because of its resemblance to nephritic cell carcinoma. By 1939, Schiller state a his tologic comparison to mesonephric tubules a! nd classified these tumors as mesonephromas. In 1944, Saphir and Lackner described two cases of hypernephroid carcinoma of the ovary and proposed clear cell glandular cancer as an alternative term. Clear cell tumors of the ovary are now generally considered to be of mullerian and in the genital tract of mullerian origin. A number of examples of clear cell adenocarcinoma have been... If you urgency to get a full essay, array it on our website: OrderEssay.net

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